A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer

Early detection of cancer disease is vital to the successful treatment, follow-up and survival patients, therefore sensitive specific methods are still required. Mucin 1 (MUC1) a clinically approved biomarker for determining that type I transmembrane protein with dense glycosylated extracellular domain extending from cell surface 200–500 nm. In this study, nanopolymers were designed lectin affinity-based recognition system MUC1 as bioactive layer on electrochemical biosensor electrode surfaces. They synthesized using mini emulsion polymerization method derivatized triethoxy-3-(2-imidazolin-1-yl) propylsilane (IMEO) functionalized Concanavalin Type IV (Con A) lectin. Advanced characterization studies performed. The operating conditions sensor have been optimized. Biosensor validation Real sample blood serum was analyzed new compared commercially available medical diagnostic kit (Enzyme-Linked ImmunoSorbent Assay-ELISA). generation nanopolymeric material has shown be an affordable, sensitive, reliable rapid device 0.1–100 U/mL linear range 20 min response time.